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For example, the endoplasmatic reticulum has a more oxidizing environment (E GSSG/2GSH = −180 mV) with respect to the cytosol (E GSSG/2GSH = −232 mV) in order to support and ensure proper protein folding and formation of necessary disulfide bridges [108,157]

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151,152 The prevalence of hypoglycemia unawareness among individuals with diabetes on intensive insulin therapy can be as high as 30–40%